Ulinastatin – Cardiology MCQ – Answer

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  1. Urinary trypsin inhibitor

Higher plasma levels of neutrophil elastase and markedly activated neutrophils have been associated with poor response to intravenous immunoglobulin (IVIG) and coronary artery lesions in Kawasaki disease. Ulinastatin, a urinary trypsin inhibitor has been used as a suppressor of neutrophils. Patients treated with ulinastatin had lower rates of coronary artery lesions (3% versus 7%; P=0.01) [1]. Read more…

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  1. Kanai T, Ishiwata T, Kobayashi T, Sato H, Takizawa M, Kawamura Y, Tsujimoto H, Nakatani K, Ishibashi N, Nishiyama M, Hatai Y, Asano Y, Kobayashi T, Takeshita S, Nonoyama S. Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study. Circulation. 2011 Dec 20;124(25):2822-8.