NACCE – Net Adverse Clinical and Cerebral Events

NACCE – Net Adverse Clinical and Cerebral Events

Net Adverse Clinical and Cerebral Events is a new metric being measured in all recent clinical trials in cardiovascular medicine. NACCE is a composite of all-cause mortality, myocardial infarction, stroke, or major bleeding [1].
NACE was another similar acronym introduced in the in the HORIZONS Trial [2].

NACE = net adverse clinical event(s)
NACE = (MACE + major bleeding unrelated to coronary artery bypass grafting)

MACE = major adverse cardiovascular event(s). Components of MACE are death, reinfarction, ischemia-driven target vessel revascularization, and stroke.

References

  1. Feres F et al. Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial. JAMA. 2013 Dec 18;310(23):2510-22.
  2. Stone GW et al. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218-2230.