Most important cardiotoxicity of immune checkpoint inhibitors – Cardiology MCQ

Most important cardiotoxicity of immune checkpoint inhibitors – Cardiology MCQ

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Cardiotoxicity of antineoplastic drugs like adriamycin is well known. In fact regular monitoring and management of cardiotoxicity of antineoplastic drugs have given rise to a new subspeciality known as Onco Cardiology [1]. Immune checkpoint inhibitors are novel anti cancer drugs targeting immune checkpoint molecules: cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed cell death 1 (PD-1) and its ligand (PD-L1) [2]. They are highly useful in a large number of solid and hematological tumours, otherwise associated with a poor prognosis. They are distinct from targeted therapies and tumour type specific therapies.

The most important recently highlighted immune checkpoint inhibitor cardiotoxicity is:

  1. Fulminant myocarditis
  2. Acute myocardial infarction
  3. QT prolongation
  4. Venous thromboembolism

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Reference

  1. Sueta D, Hokimoto S. Onco-cardiology: Present and future. Int J Cardiol. 2016 Jul 15;215:38-40.
  2. Varricchi G, Galdiero MR, Marone G, Criscuolo G, Triassi M, Bonaduce D, Marone G, Tocchetti CG. Cardiotoxicity of immune checkpoint inhibitors. ESMO Open. 2017 Oct 26;2(4):e000247.
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