Dosage of tPA – Cardiology MCQ

Maximum dose of tPA (Alteplase) for thrombolysis in acute myocardial infarction:
 
a) 30 mg
b) 50 mg
c) 70 mg
d) 100 mg
Correct answer: d) 100 mg
 
Initial bolus of 15 mg is followed by infusion of 0.75 mg/kg over 30 minutes (maximum 50 mg), then 0.5 mg/kg (maximum 35 mg) over the next 60 minutes. Total dose administered should not exceed 100 mg.
Reteplase (rPA) is given as double bolus of 10 units each, given 30 minutes apart.

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