Fondaparinux

Fondaparinux

Fondaparinux is a synthetic polysaccharide which is an indirect, selective factor Xa inhibitor. The drug binds specifically to antithrombin III and not to irrelevant plasma proteins. It has no inhibitory effect on platelet aggregation. It has a favorable pharmacokinetic profile after subcutaneous administration like hundred percent absorption into plasma, with maximal concentration in two hours, relatively long half-life of about seventeen hours and a predictable dose response, independent of age or sex. Clearance of fondaparinux is solely by the renal route and hence renal failure with a glomerular filtration rate of less than thirty milliliters per minute would be a contraindication.