Cardiophile MD

Lown Ganong Levine (LGL) syndrome is one of the pre-excitation syndromes like the better known Wolf Parkinson White (WPW) syndrome. The electrocardiographic finding is a short PR interval with normal QRS duration, unlike the wide QRS in WPW syndrome. The description by Lown B, Ganong WF and Levine SA was in 1952 [The syndrome of [...]

Holt-Oram syndrome was described by Mary Holt and Samuel Oram as ‘ Familial heart disease with skeletal malformations’. Br Heart J. Apr 1960;22:236-42. The initial description was of familial atrial septal defects and abnormalities of the thumb and radial aspect of the upper limb. Simian thumb, in which the thumb lies in the same plane [...]

Rheolytic thrombectomy is the procedure in which a jet of saline is directed at the thrombus in the coronary artery from the tip of a catheter using an AngioJet system. The slurry is sucked through another channel of the catheter. A recent study presented at the American College of Cardiology 2010 meeting found that the [...]

Digoxin toxicity has become far less common as the use of digoxin, especially that of the loading dose has come down. Still an occasional case can occur due to renal dysfunction or drug interactions. Almost any type of arrhythmia can occur in digoxin toxicity except Mobitz type II second degree AV block and atrial fibrillation [...]

Carney complex is an autosomal dominant disorder characterised by cardiac myxomas, lentiginosis and endocrine abnormalities. The mutation associated with Carney complex is in the PRKAR1-α gene. This gene is involved in the synthesis of a subunit of protein kinase A. Lentginosis (spotty skin pigmentation) occurs often on the face and oral mucosa. Myxomatous lesions may [...]