Cardiology question / answer session 37

Nitric oxide synthase

 eNOS: endothelial nitric oxide synthase

 iNOS: inducible nitric oxide synthase

 EDHF

 endothelium derived hyperpolarising factor

 Angiotensin II receptors

 AT2 receptor: stimulation of this receptor produces vasodilatation and is anti-proliferative

AT1 receptor: stimulation produces vasoconstriction, is pro-inflammatory

Brachial artery flow mediated vasodilation

A segment of brachial artery is measured by ultrasound and proximal occlusion is applied for a period of 5 minutes. Repeated measurement is taken after 1 minute and within 10 minutes, to assess the flow mediated vasodilation. More than 10% increase in the vessel diameter is taken as a positive response.

General

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