Warfarin has a narrow therapeutic window
Low INR -> thromboembolic complications
High INR -> major bleeding
Successful management requires:
Careful monitoring of INR
Ongoing patient education
Good communication with patients
Benefits of Anticoagulant Clinics:
Randomized controlled trials found:
Lower adverse events – thromboembolism and major hemorrhage
Anticoagulant levels within the therapeutic range for a longer period – better control
Cost reduction and decreased emergency department visits